From Nanjing to synapses: Yimei Cai’s journey in neuroscience at Georgetown University
Pursuing a PhD in neuroscience is no easy task, but for 31-year-old Yimei Cai, it’s a thrilling journey driven by boundless curiosity, unshakable determination, and a deep fascination with the human brain. From unraveling the molecular secrets of neurological disorders to navigating the challenges of academic life, Nanjing-born Yimei is on a mission to push the limits of scientific discovery. In this interview, we dive into her inspiring story, exploring the power of resilience, the magic of interdisciplinary collaboration, and her relentless passion to make groundbreaking contributions to neuroscience.

What do you love the most about your degree so far?
Probably, the fact that I have the opportunity to work with brilliant scientists from various disciplines. The lab environment is dynamic and collaborative, allowing constant exchanges of ideas. Plus, the thrill of using many different methodologies to uncover new insights keeps me motivated and excited about the future of my research.
How is your degree innovative?
My PhD research focuses on understanding how certain genes, linked to Autism Spectrum Disorder (ASD), affect the development and function of synapses in the brain. I use advanced techniques to create model organisms with specific genetic mutations seen in human patients; this helps me study how these mutations impact brain cell connections and communication. The research not only provides insights into how synapses work, but also reduces the gap between genetic changes and the symptoms of ASD, potentially leading to new treatments.
What does this scholarship mean to you?
The Dompé Foundation scholarship is an important recognition of my hard work and dedication to my research. The financial support has had a meaningful impact on my daily life, easing financial stress and allowing me to focus more on my work. Additionally, being part of this scholarship community connects me with other talented scientists who share my passions, creating opportunities for collaborations and inspiring new ideas.

Tell us about an experience abroad during your time at university
Although I was born and raised in China, I chose the United States as my destination for my higher education - from my undergraduate studies to my PhD research - because it offers cutting-edge research technologies and facilities and the chance to engage with some of the world’s most innovative minds. Living in the US gave me the opportunity to dive into a multicultural environment and meet people from all over the world; this broadened my perspective, making me more open-minded and adaptable. It also helped me to embrace and appreciate my own cultural roots.
What was your biggest dream as a child and how about today?
When I was 13, one of my biggest dreams was finding a way to treat Spinocerebellar Ataxia, a devastating disorder that progressively impairs movement control. This dream was inspired by a Japanese TV show called 1 Litre of Tears, based on the true story of a young girl who bravely battled this disease. Her story touched me deeply, and her courage made me want to contribute to the treatment of this devastating condition. Now, my goal is to make meaningful contributions to the field, playing an important role in future discoveries and treatments.

What is the best piece of advice you’ve ever been given?
The best advice I received came from my mother. She taught me that true growth comes from the ability to look honestly at one’s actions and decisions, to learn from mistakes and to be open to constructive criticisms. This wisdom has been essential in my scientific journey, where reflecting on my work and heeding feedback from peers are crucial for progress
Tell us something that is not on your resume
I have so many hobbies that I enjoy, including sports, movies, cooking, baking, singing, crafts making, traveling, and many others. Unfortunately, as a researcher, I have a very tight schedule, so it’s often difficult to find time for all of them, but I do my best. This past July, for example, while I attended a research conference in Italy, I decided to take a week afterward to travel the country and relax a bit.